I agree with Oz ... nodding my head worse than the bobbles to Babe Ruth in the recent ads.
Make sure to get a top running back. But don't obsess over it. If a top WR is there, and it's between a Holt, Harrison, CJ, Steve Smith or a "maybe" at RB, take the WR without hesitation. Take another iffy RB later.
The last two years, I went after RBs, WRs and a good TE (didn't reach for Gonzo or Gates ... usually in fourth or fifth round got a good one). Settled for a QB later. Sure, I want a top QB, but would rather have a strong RB - two if your lineup requirements state you need two or more - WR and TE, then worry about QB. With Peyton's numbers more of this Earth and Daunte Culpepper's knee getting smashed in Charlotte at midseason, that had every so-called FFL expert screaming not to put QBs on a fantasy pedestal.
On the combos, if you end up with Carson Palmer and CJ, or Peyton and Marvin, that's nice. But don't bypass perfectly good RBs or another top WR just to make this happen.