A cure for Alzheimer's?

[2muchcoffeeman]

Dementia killed my mother, my maternal grandmother, and two of her three sisters. I always figured it would come for me.

But what if it doesn't?

From a Reddit post:

Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well!!!!)​

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

I hope this bears fruit.

 

[micropolitan guy]

Dementia killed my mother, my maternal grandmother, and two of her three sisters. I always figured it would come for me.

But what if it doesn't?

From a Reddit post:

​

Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.​

​

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well!!!!)​

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

I hope this bears fruit.

I'm sure RFK Jr. will pull out all the stops to increase research and funding, and attempt to hasten the drug's approval for use. He's all about keeping us healthy.

Seriously, even if it doesn't work on every patient, what's been hurt?

 

[dixiehack]

Dying from dementia (my likely fate) does not bother me. After all I’m going to die from something.

Living with dementia, especially the burden it would put on my kids, terrifies me.

 

[Shelbyville Manhattan]

Sadly, my first thought went to RFK Jr., too.

I'll never forgive the voters for electing a president who put that ******* crank in charge of health in this country.

I'm sure RFK Jr. will pull out all the stops to increase research and funding, and attempt to hasten the drug's approval for use. He's all about keeping us healthy.

Seriously, even if it doesn't work on every patient, what's been hurt?

 

[Pickleballgolds]

Being able to prevent/reverse Alzheimer’s would be the greatest medical breakthrough of all time.

 

[Liut]

Dementia killed my mother, my maternal grandmother, and two of her three sisters. I always figured it would come for me.

But what if it doesn't?

From a Reddit post:

​

Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.​

​

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well!!!!)​

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

I hope this bears fruit.

Thank you for sharing. My mother suffered from dementia and I was her primary care-giver until near the end.

 

[TigerVols]

Dying from dementia (my likely fate) does not bother me. After all I’m going to die from something.

Living with dementia, especially the burden it would put on my kids, terrifies me.

I too am likely to die from it (family history plus having had 12 concussions) but I won’t live very long with it, know what I mean?

 

[BTExpress]

If the miracle drug does come, count on the price tag being $18,000/month.

 

[dixiehack]

I too am likely to die from it (family history plus having had 12 concussions) but I won’t live very long with it, know what I mean?

The tricky part is hitting the sweet spot where you understand what is happening and can follow through with that plan without depriving yourself of some really good years in the meantime.

 

[Slacker]

If the miracle drug does come, count on the price tag being $18,000/month.

 

[BitterYoungMatador2]

I too am likely to die from it (family history plus having had 12 concussions) but I won’t live very long with it, know what I mean?

When I saw one of the states that permits it is Hawaii I said to my wife, "well, guess that's settled."

I watched my grandfather wither away from Alzheimer's, it is my greatest fear that my mom will get it one day, considering I am an only child and she was a single mom and, for many years, we were it. And if I get it, I've already instructed people to Kevorkian me.

 

[DanOregon]

My mom has memory lapses. She's still "present" 100 percent of the time, but we'll talk about things from our childhood, or family members that she cannot place at all. And she's always had a problem with lateness, focus, being on time. But I never realize the ability to keep track of time, gauge how long it might take to complete a task, (let alone the challenges of completing the task when you are older) is something that declines with age. While not Alzheimer's or dementia - it is in the "family" so to speak.

 

[wicked]

Dementia has touched our family, and I hope this is a turning point.

 

[wicked]

I'm sure RFK Jr. will pull out all the stops to increase research and funding, and attempt to hasten the drug's approval for use. He's all about keeping us healthy.

You know it will be pushed through because Alzheimer’s runs in the Trump family and the guy can’t remember what ocean we bombed last.

 

[Neutral Corner]

If the miracle drug does come, count on the price tag being $18,000/month.

That's ok. Trump will get us a 600% discount!

 

[WolvEagle]

My late maternal grandmother had dementia and now my mom has it. My parents are in assisted living, thankfully.

There were seven of us in her room the other day for a post-Christmas gathering. Six of us were carrying on a conversation and she slept through the whole thing. She smiled once without opening her eyes.

When I remember who she was -- a strong-willed woman who had successful careers in real estate and banking -- and see what she is now, sleeping most of the time and having imaginary conversations when she's awake, man, it sucks.

 

[dixiehack]

Only a matter of time until my dad slips below the line and fully succumbs. He already has more frequent moments of misfiring neurons and family history indicates that dementia is a near-certainty for him (and almost as certain for me).

 

[HanSenSE]

Last few visits with my grandmother were interesting. One night mom bought her to her home for a birthday celebration, the day Pedro and Zimmer went at each other, and she kept asking, "Why did they fight?" The last was when I came back from Lake Havasu City for my first visit, we went to where they were caring for her, and every 20 minutes she asked what I like about Arizona. I kept trying to come up with original answers like "the people are nice," "the weather is nice," and, finally, "regular paychecks." Later my brother mentioned to me that if you missed something in a conversation with her, you'd have the same conversation later in the visit.

 

[Shropshire Slasher]

My mom died of frontotemporal dementia, not Alzheimer's. She went down pretty fast, but not fast enough to avoid pissing away every every cent she saved on memory care. The first thing that went was her speech.

On the other hand, my dad just turned 82 and is doing great, and all four of his siblings are still thriving. Mamaw lived to 95 and got laid low by (I suspect) early undetected covid (February 2020). That side of the family has good genes. So we'll see which side of the coin I get.

 

[Liut]

My late maternal grandmother had dementia and now my mom has it. My parents are in assisted living, thankfully.

There were seven of us in her room the other day for a post-Christmas gathering. Six of us were carrying on a conversation and she slept through the whole thing. She smiled once without opening her eyes.

When I remember who she was -- a strong-willed woman who had successful careers in real estate and banking -- and see what she is now, sleeping most of the time and having imaginary conversations when she's awake, man, it sucks.

Yes, it does.