You can feel comfortable and toasty-warm in the middle of winter if you dress properly.
Maybe if you have spent your entire life in such a climate. Otherwise . . . no.
http://www.independent.co.uk/travel/europe/yakutsk-journey-to-the-coldest-city-on-earth-771503.html
"Lumbering from my hotel room like the Michelin Man, and already breaking into a sweat due to the hotel's industrial heating system, I decide that I'm ready to face everything Yakutsk has to throw at me. I stride purposefully out of the hotel door and... well... it really isn't that bad. The small oblong of my face that is naked to the elements definitely registers the cold air, but on the whole, it feels fine; pleasant, even. As long as you're dressed right, I think, this isn't too bad.
Within a few minutes, however, the icy weather begins to assert itself forcefully. The first place to suffer is the exposed skin on my face, which begins to sting, and then experience shooting pains, before going numb, which is apparently dangerous, because it means blood flow to the skin has stopped. Then the cold penetrates the double layer of gloves and sets to work on chilling my fingers.
The woolly hat and padded hood are no match for minus 43C either, and my ears begin to sting. Next to succumb are the legs. Finally, I find myself with severe pain all across my body and have to return indoors. I look at my watch. I have been outside for 13 minutes."