I know an air marshall who told me about a guy who did this on a flight from NYC to Atlanta several years ago.
Went to the loo, came out naked, straddled one or two passengers to get to his window seat (ewwww) and was acting hyper. Wouldn’t follow commands. Finally the Marshall got her point across that bad **** would happen if he didn’t comply. Said he went from wild to docile in a snap. They put him in restraints, covered with blankets and took him off the plane when they landed.
Guy spent four days in the Atlanta fed lockup before he and his family could show proof it was a bad combo of medicine that caused him to wig out.
Also, at the time, she said every major east coast flight had at least two if not three Marshalls on board. They blend in well.