Fat Head's Saloon isn't in downtown (south side) but isn't far, either. Great beers, the smoked wings are outstanding and the sandwiches are massive and tasty. Only been to the Pittsburgh location once, but have visited the flagship in Cleveland several times. They don't brew on-site (all the FH beers are from their production brewery outside Cleveland) but have many of their own brews along with a very credible guest tap list (if you're into that beer thang).
Other than that, I got nothin'. Been a few since I've visited. Really want to make a PNC Park visit soon.